It has sekretomotornym, sekretoliticheskim and expectorant action. testosterone cypionate price stimulates the motor activity of the cilia of the ciliated epithelium of the bronchial mucosa (mucokinetic sekretomotornym or action). Peristaltic contraction spiral ciliated (ciliary) bronchial epithelial cells derive mucus from the bronchial tree (mucociliary transport or mucociliary clearance). testosterone cypionate price improves mucociliary transport. testosterone cypionate price stimulates serous cells of glands of bronchial mucosa, increases the amount of mucous expectoration component and normalizes impaired ratio of serous and mucous components of phlegm. By activating the hydrolyzing enzymes and increasing the release of lysosomes of Clara cells, reduces the viscosity of sputum viscosity and its adhesive properties (or sekretoliticheskoe mucolytic action). testosterone cypionate price increases the synthesis and secretion of surfactant (surfactant) in the alveoli and bronchi.
As a result of these mechanisms is significantly reduced sputum viscosity and improving its expectoration.
After oral administration, the action occurs within 30 minutes and lasts for 6-12 hours.
Absorption – high (if any routes of administration), time to maximum concentration -2 h contact with plasma proteins – 80%. It penetrates through the blood-brain barrier, placental barrier, excreted in breast milk. Metabolism – in liver forms dibromantranilovuyu and glucuronic acid conjugates. . The half-life – 7-12 hours excreted by the kidneys: 90% in the form of water-soluble metabolites in unmodified form – 5%. The half-life is increased in severe renal insufficiency, it does not change with impaired hepatic function.
Acute and chronic diseases of the respiratory tract, accompanied by the release of viscous mucus:
- acute and chronic bronchitis;
- chronic obstructive pulmonary disease;
- bronchial asthma with obstruction of sputum discharge;
Hypersensitivity, pregnancy (I term), age 12 years (children under 12 years: Bronhorus in the form of syrup). In the case of lactose intolerance should be considered (the syndrome of malabsorption of glucose / galactose or failure of sucrose / isomalt) that the drug includes lactose.Precautions
Liver failure, renal failure, gastric ulcer and duodenal ulcer, pregnancy (II-III trimester), lactation.
Dosing and Administration
Inside, after eating, drinking plenty of liquid. Adults and children over 12 years -. 1 tablet (30 mg) 3 times a day if necessary to enhance the therapeutic effect can be given 2 tablets (60 mg) 2 times a day. in severe cases, the dose is not reduced during the course of treatment. Children under 12 years Bronhorus administered in syrup form. It is not recommended to take the drug for more than 5 days without consulting a doctor.
Allergic reactions: skin rash, urticaria, angioedema, in some cases – allergic contact dermatitis, anaphylactic shock.
Rarely – general weakness, headache, diarrhea, dysuria, rash, runny nose, constipation.
With prolonged use at high doses – gastralgia , nausea, vomiting.
Overdosing Symptoms: nausea, vomiting, diarrhea, dyspepsia. Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug; reception of fat-containing products.
Interaction with other drugs
combined use of antitussive drugs leads to difficulty sputum discharge on the background to reduce coughing.
Increases penetration in bronchial secretion of amoxicillin, cefuroxime, erythromycin and doxycycline.
should not be combined with antitussive drugs that prevent removal of phlegm.