Pharmacodynamics mucolytic and expectorant action is caused by the activation of sialic transferase – an enzyme goblet cells of bronchial mucosa. It normalizes the proportion of acid and neutral sialomutsinov bronchial secretions. Reduces the viscosity of bronchial secretions, and discharge from the sinuses, facilitates expectoration of phlegm and mucus, reduce cough. It promotes the regeneration of the mucous membrane and normalizes its structure, activates the activity of ciliate epithelium. Restores the secretion of immunoglobulin IgA (specific protection) and the number of sulfhydryl groups mucus components (non-specific protection), improves mucociliary clearance. Pharmacokinetics testosterone cypionate injection rapidly absorbed after oral administration.Bioavailability – low (less than 10% of the dose). The maximum concentration in serum and respiratory tract mucosa is achieved 2-3 hours after oral administration and is stored in the mucosa for 8 hours. It is metabolized in the liver (which has the effect of “first pass” through the liver). Write mainly kidneys, partly unchanged, partly in the form of metabolites. The half-life of about 2 hours.
Acute and chronic bronchopulmonary diseases accompanied by formation viscous sputum (tracheitis, bronchitis, bronchitis, asthma, bronchiectasis) and mucus (an inflammatory disease of the middle ear, nose and paranasal sinuses – rhinitis, otitis media, sinusitis) preparation for bronchoscopy and / or bronhografii.
: Hypersensitivity to testosterone cypionate injection or other components of the drug, gastric ulcer and duodenal ulcer in the acute stage, chronic glomerulonephritis (exacerbation), cystitis, children under 15 years, pregnancy (I term).
Precautions: while taking the drug in chronic glomerulonephritis (in history), gastric ulcer and duodenal ulcer (in history), pregnancy (II-III trimesters) and during breastfeeding.
Pregnancy and lactation
In II and III trimester of pregnancy, the drug is prescribed only when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should decide the issue of termination of breastfeeding.
Dosage and administration
For oral administration. Adults and adolescents over 15 years: 750 mg (2 capsules) three times a day. After achieving a therapeutic effect daily dose reduced to 1.5 g: 750 mg (2 capsules) twice a day.Treatment should not last more than 8-10 days without consulting a doctor.
Side effect On the part of the gastrointestinal tract: sometimes marked nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding. Allergic reactions: itching, hives, rash, angioedema. Other:dizziness, weakness, malaise.
Overdose Symptoms: gastralgia, nausea, diarrhea. Treatment: symptomatic.
Interaction with other drugs
testosterone cypionate injection increases the efficiency of glucocorticosteroid and antibacterial therapy of inflammatory diseases of the upper and lower respiratory tract, potentiates the bronchodilator effect of theophylline.testosterone cypionate injectiona activity weakens antitussive agents and atropine.
In patients with gastric ulcer and duodenal ulcer in the history of the dose should be reduced. Treatment can be combined with physical therapy.
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