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testosterone cypionate vs enanthate

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Synthetic glucocorticosteroid test cypionate vs enanthate for the topical (inhaled) applications, has anti-inflammatory, anti-allergic and immunosuppressive effect. It increases production lipomodulina, an inhibitor of phospholipase A, inhibits the release of arachidonic acid, inhibits the synthesis of products of arachidonic (buy testosterone cypionate) acid metabolism – cyclic endoperikisey and prostaglandins.It prevents the accumulation of neutrophils boundary, reduces the inflammatory exudation and production of lymphokines inhibits the migration of macrophages, reduces the intensity of infiltration and granulation processes, the formation of chemotactic substances (which explains the efficacy in the “late” reactions, allergies); inhibits the release of mast cell inflammatory mediators ( “immediate” allergic reaction). It increases the number of active beta-adrenergic receptors, eliminating their desensitization (restores the patient’s response to bronchodilators, allowing you to reduce the frequency of their use) reduces the bronchial testosterone isocaproate mucosa swelling, mucus production. It improves mucociliary transport. Well tolerated in long-term treatment has not mineralokortikosteroidnoy activity almost no resorptive action.

Pharmacokinetics
Absorption – low. After inhalation of 20-25% reaches the small bronchi, the dose received by the gastrointestinal tract (GIT) is absorbed and almost completely (90%) of biotransformation in the liver to inactive metabolites. Bioavailability -10% of incoming number in the stomach and 28% – for pulmonary fraction. Time of occurrence of the maximum concentration in blood plasma – 15-45 minutes after inhalation. Relationship to plasma proteins – 88%. It has a high systemic clearance – 84 l \ h. The half – 2.8 h, the maximum plasma concentration – 0.01 mmol \ l. Is displayed through the intestine as metabolites – 10%, kidneys 70%.

Indications
Budekort prescribed as a basic anti-inflammatory agent in various forms and degrees of severity of asthma (including hormone-dependent -for reducing the dose of oral corticosteroids); the lack of effectiveness of bronchodilators and \ or kromoglitsievoy acid and nedocromil sodium; in chronic obstructive pulmonary disease (COPD) – with varying severity of airway obstruction.

Contraindications
: Hypersensitivity and idiosyncrasy of the drug.

Pulmonary tuberculosis (active form), bacterial and viral infections of the respiratory, acute bronchospasm, asthmatic status (as a priority means), bronchitis neastmaticheskoy nature. Children under 6 years of age.

Be wary – cirrhosis, glaucoma, hypothyroidism, bacterial, fungal, parasitic and viral infections (including amoebiasis, tuberculosis, herpes of the lips and eyes), osteoporosis.

Note: Caution should be exercised when administered to patients during pregnancy and lactation.

Dosing and Administration
Budekort used by inhalation, using a metered-dose aerosol inhaler. A single dose contains 100 micrograms or 200 micrograms of testosterone cypionate vs enanthate.

The daily dose Budekorta selected individually, taking into account the severity of the asthma and the maintenance dose of oral glucocorticosteroids. In adults, for the maintenance treatment is typically fairly 200 – 800 mcg of testosterone cypionate vs enanthate per day. During an exacerbation of asthma testosterone cypionate vs enanthate dose should be increased to 800 – 1600 mg per day.

The maximum daily dose is 2,000 mg \ day.

The daily dose of inhaled Budekorta in 2 – 4 divided doses. Duration of treatment 3 – 12 months, depending on the severity of asthma.

Children from 6 years to designate 100 – 200 mg 2 times per day, or 200 – 400 mg 1 time per day. The maximum daily dose for children is 400 mg 2 times a day.

In those cases where the patient receives the SCS inwardly move Budekortom treatment follows in a stable phase of the disease. First, you need to combine inhaled testosterone cypionate vs enanthate with continued receiving corticosteroids orally for 14 – 20 days. After that produce a gradual reduction in the dose of drugs taken by mouth, until their complete abolition, if possible.

Preliminary inhaled beta2-agonists (salbutamol) extends bronchi and improves the flow of testosterone cypionate vs enanthate in the airways, thereby enhancing its therapeutic effect.

Instructions for the patient on the use of metered-dose aerosol inhaler

PART inhalers

How to use Inhalers

Checking inhaler
before using the inhaler for the first time, or if he has not been used for a week or longer, shake the inhaler and then try it in action, do so by pressing on the valve until the aerosol cloud.

The use of an aerosol inhaler

1. Remove the mouthpiece cover and check the mouthpiece clean. Before each use, thoroughly shake the bottle. Take the inhaler as shown in the figure, between the thumb and forefinger.

2. Take a slow breath through your mouth

3. Take the mouthpiece into your mouth and place it between the teeth, lips tightly clasped. Begin to inhale slowly through your mouth. At the same time, press on the bottom of the container, making the one-touch, continuing to breathe deeply

4. Remove the inhaler from the mouth and hold your breath for 10 seconds or at the most comfortable for you time. Take a relaxing breath.

5. If there is a need for additional dose wait for at least 1 minute. Carefully shake the bottle and repeat steps 2-4. After use, set the mouthpiece cover.

Special instructions.
Do not change the sequence of steps 3 and 4. It is important to breathe calmly through the mouth prior to clicking on the balloon. The first time you work out in front of a mirror. If you notice an aerosol cloud emerging from the inhaler or from your mouth, repeat the sequence from step 1.

FOR CHILDREN
Children who need to use an inhaler, you may need help from their parents.

Caring for an aerosol inhaler.

For the successful operation of the inhaler It is important that the plastic mouthpiece was clean. Care for the inhaler at least 1 time per week, as follows:

  1. Carefully remove the balloon from the inhaler adapter. Remove the mouthpiece cover
  2. Lower the adapter at a time and the mouthpiece cover in warm water. Do not immerse in water a metal cylinder.
  3. Wash the plastic mouthpiece adapter and running water
  4. Carefully shake the adapter to remove the remaining water. Leave to dry. Avoid heating.
  5. Place the cylinder in the adapter and set the mouthpiece cover.

Note
Use an aerosol inhaler only on the advice of your doctor. If the use of the recommended dose of the drug is not accompanied by a decrease in symptoms or the deterioration, contact your doctor.
Do not exceed the set dose.
The container is under pressure. Do not pierce or burn, even if the bottle is empty.
Keep out of the reach of children.
Do not freeze.

Side effects:
Hoarseness, cough, resulting from the settling of the drug in the oropharynx. Irritation of the throat and oral mucosal candidiasis, xerostomia, oral candidiasis, headache, nausea, changes in taste sensations, bruising; rarely – paradoxical bronchospasm, esophageal candidiasis, mental changes (anxiety, restlessness, depression, behavioral changes). High doses may cause the development of systemic side effects of corticosteroids.

Interaction with other drugs
in the treatment of bronchial asthma Budekort well with beta2- agonists, kromoglitsievoy acid or nedocromil sodium, methyl xanthines and iprotropiya bromide. Phenobarbital, phenytoin, rifampin reduce the effectiveness (induction of enzymes of microsomal oxidation).

Methandrostenolone, estrogens increase the effect of testosterone cypionate vs enanthate. Information about the interaction of ketoconazole with inhaled testosterone cypionate vs enanthate is not, however, expect a noticeable increase in drug concentration in blood plasma.

Cautions
For acute, severe attack of asthma (status asthmaticus) the drug is not a means of “first aid”.

It is necessary to strictly observe the instructions for use of the inhaler. After inhalation, it is recommended to hold their breath for 10 seconds.

High doses may cause children to slower growth rate and a decrease in the secretion of hydrocortisone, so these parameters recommended constantly monitored during treatment.

It is recommended to avoid contact with eyes. After the drug is recommended to rinse your mouth with water to reduce the risk of thrush.

Omitting the drug dose to be applied all the remaining doses on the same day at regular intervals and used as soon as possible.

The drug should not freeze or expose to direct sunlight. The balloon can not puncture, disassemble or dispose of in fire, even if it is empty. Upon cooling spray is recommended to get it out of the plastic case and warm hands (at low temperatures the efficiency of the drug is reduced).

Product Form
In 15 g of an aluminum container fitted with a metering valve. The balloon with a plastic inhaler and instructions for use in a carton box.

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About testosterone cypionate results 6 g (1 tablespoon) of crushed leaves cranberries are placed in an enamel bowl, pour 200 ml (1 cup) of hot boiled water, close lid and heated in a boiling water bath for 30 minutes, then filtered without cooling, the remaining raw materials squeeze. The volume of the resulting broth was adjusted with boiled water to 200 ml.
It is taken testosterone cypionate results 1-2 tablespoons 3-4 times testosterone cypionate results a day 40 minutes after eating. The course of treatment 20-25 days. Perhaps a repeat course after 10-12 day break, but not more than 4 courses per year.
Must be shaken before use broth.

Side effects
are possible allergic reactions.

Product Form
In 35 g, 40 g, 50 g, 60 g, 75 g, 100 g of crushed leaves in cardboard packs with an internal packet.
The full text of instructions is applied to the stack. sustanon benefits scamner.com organon pharmaceuticals steroids

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A mixture of non-uniform testosterone cypionate reviews particles of leaves, stems, flowers, pericarp, fruit, petals, twigs and stems from light green to dark green, sometimes from light brown to brown, orange-red, yellow-white color.The smell is weak. Water extraction taste bitter, astringent.The mixture is non-uniform particles of leaves, stems, flowers, pericarp, fruit, petals, twigs and stems greyish-green with whitish-yellow and brownish-red, brown and dark brown patches.The smell is weak. Water extraction taste bitter, astringent.

Pharmacotherapeutic group:
antimicrobial, anti-inflammatory and diuretic herbal.

Pharmacological action
The infusion testosterone cypionate reviews and decoction of the collection have antimicrobial (against Staphylococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus and other microorganisms), anti-inflammatory, diuretic effect.

Indications for use
The infusion and decoction is used as an antimicrobial, anti-inflammatory and diuretic in the treatment of acute and chronic diseases in urology (cystitis, urethritis, prostatitis), gynecology (vaginitis, vulvitis nonspecific etiology) and proctology (proctitis, inflammation of hemorrhoids, anal crack, colitis).

Contraindications
: Hypersensitivity to the drug.

Dosing and Administration
Brusniver administered orally or topically in the form of infusion or decoction.

Broth: about 8 grams (4 teaspoons) collection is placed in an testosterone cypionate reviews enamel bowl, pour 500 ml (2.5 cups) of boiling water, insist for 1 hour, boil with the lid on low heat for 15 minutes, again insist at room temperature 45 minutes, filtered, the remaining raw materials squeeze.

Infusion: 2 filter bags (4 g) the collection placed in a glass or enamel bowl, pour 200 ml (1 cup) of boiling water, cover and insist 30 minutes, occasionally pushing the spoon bags, then squeeze them.

Before use, the broth (infusion) is recommended to shake.

Inside the broth (infusion) is prescribed in the form of heat for 1 / 4-1 / 3 cup 3-4 times a day.

Locally warm broth (infusion) is used undiluted for mikroklizm 25-50 ml; for irrigation, douches, baths, lotions decoction (infusion) is diluted by 2-4 times.

In urology broth (infusion) administered orally on the above scheme within 1-3 weeks. In chronic course of the disease course of treatment can be increased up to several months in consultation with a physician. Simultaneously broth (infusion) may be administered topically (microclysters) for 1-2 weeks, 1-2 times per day.

In gynecology broth (infusion) administered testosterone cypionate reviews orally according to the scheme for 2-4 weeks at a time locally (baths, irrigation, irrigation, lotions, microclysters) 1-2 times a day.

In proctology broth (infusion) are used for 1-3 weeks at a time into 1 / 4-1 / 3 cup and topically as a lotion warm 1-3 times a day and 50 ml mikroklizm overnight.

When colitis broth (infusion) are used only inside.

Side effects
are possible allergic reactions.

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testosterone enanthate vs cypionate

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Broad-spectrum antibiotic of the aminoglycoside. Bacteriostatic testosterone enanthate vs cypionate. Highly active against testosterone enanthate vs cypionate gram-negative bacteria (Pseudomonas aeruginosa, Acinetobacter spp., Esherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Proteus spp., Salmonella spp., Shigella spp.), As well as some gram microorganisms: Staphylococcus spp. (including those resistant to penicillins, cephalosporins), certain strains of Streptococcus spp.Aminoglycosides in combination with penicillins or cephalosporins some effective for treating infections caused by Pseudomonas aeruginosa and Enterococcus faecalis.
After intramuscular administration of the drug is rapidly distributed to organs and tissues. It penetrates through the placenta. Maximum serum concentration is detected through 40-90 minutes after administration; drug when administered intramuscularly at a dose of 1 mg / kg of patient body weight maximum plasma concentration of 3-7 mg / l. Therapeutic concentration is maintained for 8 hours. The half-life (T1 / 2) with normal renal function – 2 hours. 80-84% of the administered dose is excreted through the kidneys in unchanged form, 10-20% – through the intestines.

T1 / 2 in newborns – 5-8 hours, in children older – 2.5-4 h final T1 / 2-more than 100 hours (release from intracellular stores).. In patients with renal insufficiency T1 / 2 varies depending on the degree of failure – to 100 hours, and testosterone enanthate vs cypionate in patients with cystic fibrosis – 2.1 hours, in patients with burns and hyperthermia may be shorter compared to the average performance owing to the increased ground clearance. In hemodialysis removes 25-70% of the administered dose.

Indications for use.
Infectious diseases caused by sensitive microflora: biliary tract infections, bone and joints (including osteomyelitis), central nervous system (including meningitis), abdominal (including peritonitis) respiratory (including pneumonia, empyema, lung abscess), skin and soft tissues (including infected burns), urinary tract infections (including pyelonephritis, pyelitis, cystitis), sepsis, post-operative infections .

Contraindications.
Hypersensitivity to tobramycin and other aminoglycoside antibiotics, neuritis of the auditory nerve, severe chronic renal failure (CRF), pregnancy, lactation.

Precautions – Renal insufficiency, botulism, myasthenia gravis, Parkinson’s disease, dehydration, advanced age, impaired hearing.

Application of pregnancy and lactation.
If tobramycin is used during pregnancy, or pregnancy occurs during treatment with tobramycin, the patient should be informed about the possible hazard to the fetus as well as testosterone enanthate vs cypionate antibiotics aminoglycoside cross the placenta and can cause the development of total irreversible bilateral deafness in newborns.

If necessary, the appointment during lactation, breast-feeding should be discontinued during treatment.

Dosage and administration.
The drug is administered intramuscularly and intravenously.

Intramuscular administration – the contents of the vial were dissolved in 3 – 5 ml of a 0.5% solution of procaine or water for injection.

When administered intravenously – diluted in 100-200 ml of 0.9% sodium chloride or 5% dextrose solution, are administered for 20-60 min.

Single dose for adults and children older than 1 year – 1 mg / kg body weight, sutochnaya- 3 mg / kg of body weight; maximum daily dose-5 mg / kg body weight.

Children aged 1 week to 1 year: 6-7.5 mg / kg per day, parameter separated by 3-4 identical doses (at 2-2.5 mg / kg every 8 hours or 1.5-1.89 mg / kg every 6 hours) or newborn .Nedonoshennye to 1 week life. to 4 mg / kg per day, divided into 2 equal doses every 12 hours usual duration of the treatment – 10.7 days. In severe and complicated infections is possible over a longer course of therapy (under the control of renal function, state of hearing and vestibular apparatus, as a manifestation of neurotoxicity is most likely in excess of the course of treatment of 10 days).

In chronic renal failure and in patients in the elderly should reduce the dose and increase the intervals between doses. the dose is calculated as follows: the interval between injections in hours equal to the concentration of creatinine in serum, multiplied by 8; dose are the same as in normal kidney function; the initial single dose similar to the dose administered to patients with normal testosterone enanthate vs cypionate renal function, and is 1 mg / kg body weight.

Side effect.
From the digestive system: nausea, vomiting, diarrhea, abnormal liver function (increased activity of “liver” transaminases, LDH, hyperbilirubinemia).

From the side of blood: anemia, leukopenia, granulocytopenia, thrombocytopenia, leukocytosis.

From the nervous system: headache, neurotoxic effects (muscle twitching, paresthesia, seizures); rarely – neuromuscular blockade (difficulty in breathing, drowsiness, weakness).

From the senses: ototoxicity (partial or complete bilateral deafness, ringing hum or a feeling of “fullness” in the ears), vestibular and labyrinth disorders (discoordination, dizziness, nausea, vomiting, unsteadiness).

From the urinary system: nephrotoxicity (oliguria, cylindruria, proteinuria, a significant increase or decrease in frequency of urination, polyuria; the signs of kidney failure – increase in the concentration of creatinine and urea nitrogen, thirst, loss of appetite, nausea, vomiting).

Allergic reactions: itching, skin redness, rash, fever, angioedema, eosinophilia.

Laboratory findings: hypocalcemia, hyponatremia, hypomagnesemia.

. Overdose Symptoms: The toxic effects (hearing loss, ataxia, dizziness, urinary disorders, thirst, loss of appetite, nausea, vomiting, ringing or a sensation of laying in the ears, nefronekroz – increasing testosterone enanthate vs cypionate concentrations of urea, hypercreatininemia, proteinuria, oliguria), paralysis of the respiratory muscles. Treatment: patients with normal renal function is performed fluid infusion and forced diuresis; patients with impaired renal function – hemodialysis or peritoneal dialysis. If neuromuscular blockade – anticholinesterase drugs, calcium salts; when you stop breathing – an artificial lung ventilation (ALV), the other symptomatic and supportive therapy.

Interaction with other medicinal products.
Tobramycin enhances the action of non-depolarizing muscle relaxants.

It reduces the effect of antimiastenicheskih drugs.

Aminoglycosides, cephalosporins, vancomycin, polymyxin B, diuretics increase the risk of Oto-and nephrotoxicity.

Beta-lactam antibiotics weaken the effect.

Intravenous indomethacin reduces the renal clearance of tobramycin, povshaya concentration in the blood and increasing the half-life (T1 / 2) (may require correction dosing regimen).

Methoxyflurane increases the risk of side effects.

Medicaments for inhalation general anesthesia (halogenated hydrocarbons), narcotic analgesics, transfusion of large quantities of blood to citrate as anticoagulants preservatives, drugs that block neuromuscular transmission, increase testosterone enanthate vs cypionate neuromuscular blockade.

Special instructions.
In the period of treatment is necessary to control the function of the kidneys, liver, vestibular and hearing (at least 1 time per week), to monitor the concentration of tobramycin in serum, which should not exceed 8 mg / ml.

When poor audiometric test dose reduce or stop treatment.

The risk of Oto-and nephrotoxicity significantly increases with long-lasting plasma concentrations above 12 mcg / mL.

The likelihood of nephrotoxicity was higher in patients with impaired renal function, as well as in high doses or for a long time (in these patients may require daily monitoring of renal function).

Aminoglycosides penetrate into breast milk in small amounts (because they are poorly absorbed from the gastrointestinal tract associated complications were reported in infants).

the development of superinfection may occur during therapy.

In the absence of positive clinical dynamics should be aware of the possibility of development of resistant organisms. In such cases it is necessary to cancel the treatment and initiate appropriate therapy.

By increasing the volume of distribution of the drug (burns, peritonitis, retroperitoneal infection) to achieve the effective concentration of the dose should be increased, and in critical conditions and in young patients with high minute volume of blood circulation (IOC) and the rate of glomerular filtration – to increase the rate of introduction.

Product form.
The solution for intravenous and intramuscular administration of 40 mg / ml.
The solution in the vials with 1 ml of a point (40 mg / ml) or 2 ml (80 mg / 2 ml).
At 5 vials per blister PVC / Alu. Two blisters in a cardboard box with instruction on the medical application. shop steroids dmz prohormone steroidwithdrawal.biz

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Testosterone cypionate injections is a combination drug with antitussive and bronchodilator effects.Testosterone cypionate injections has a suppressive effect on testosterone cypionate injections the cough center, without affecting breathing. Has weak and bronchospasmolytic and sekretoliticheskim action. Ephedrine – sympathomimetic agent, stimulates respiration, dilates the bronchi and reduces the swelling of the mucous membrane. The essential oil of basil has anti-inflammatory and mild antiseptic effect.glaucine and ephedrine are well absorbed in the digestive tract, creating and maintaining the necessary therapeutic blood plasma levels. Distinguished primarily urine.The drug is used in combination therapy for the treatment of acute and chronic bronchitis, tracheobronchitis, bronchial asthma, whooping cough to eliminate cough and bronchoconstriction.

Contraindications
: Hypersensitivity to the drug’s components.
Coronary heart disease, hypertension, heart failure, arrhythmias, coronary atherosclerosis, pheochromocytoma, thyrotoxicosis, angle-closure glaucoma, diabetes, hyperthyroidism, prostatic hypertrophy, insomnia, pregnancy, lactation; Children up to age 3 years.
With care -. patient prone to the development of drug dependence
due to the ethanol content in the drug should use caution in patients with liver disease, alcoholism, epilepsy, brain diseases, pregnant women and children.

Dosing and Administration
Inside.
Adults – 1 tablespoon 3-4 times a day.
Children from 3 to 10 years – 1 teaspoon 3 times a day.
Children over 10 years – 2 teaspoons 3 times a day.

SIDE EFFECTS from the cardiovascular system : tachycardia, arrythmia, increased blood pressure. Co is the nervous system : tremor, agitation, insomnia, dizziness. From the digestive system : nausea, vomiting, anorexia and constipation. From endocrine system : libido enhancement , dysmenorrhea. from the urinary system : difficulty urinating, urinary retention in patients with benign prostatic hyperplasia.skin and mucous membranes : rash, increased sweating. Other : visual disturbances, tachyphylaxis. children – drowsiness.

Overdose :

Symptoms: nausea, vomiting, loss of appetite, agitation, poor circulation, limb tremor, dizziness, sweating, difficulty urinating. Treatment: gastric lavage and symptomatic agents.

Interaction with other drugs
Bronholitin can be used simultaneously with antibiotics, antipyretics and vitamins. Due to the presence in the composition of the drug ephedrine, it is necessary to bear in mind testosterone cypionate injections its drug interactions: weakens the effects of narcotic and hypnotic drugs. When applied simultaneously with cardiac glycosides, quinidine, tricyclic antidepressants increase the risk of arrhythmias. In an application with reserpine and monoamine oxidase inhibitors possible sharp rise in blood pressure, with a non-selective beta-blockers decrease of bronchodilator action.
No data on adverse drug interactions glaucine with other drugs.

special instructions

  • Despite the fact that BRONHOTON not addictive, given the composition of the drug, prescribed with caution in patients who are prone to the development of drug dependence;
  • The presence of ephedrine requires special attention when administering testosterone cypionate injections the drug to patients suffering from hypertension, since it causes a peripheral vasoconstriction.
  • Not recommended to prescribe the drug to patients with diabetes mellitus, as ephedrine, used in doses exceeding therapeutic, increases metabolism, thus leading to increase blood sugar levels.
  • We do not recommend the use of high doses drivers.

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